"Girls, Girls, Girls" is the second single from rapper Jay-Z's album The Blueprint. It is a playful description of the artist's promiscuous lifestyle. The song contains a sample of "There's Nothing In This World That Can Stop Me From Loving You" by Tom Brock. The chorus features a lyrical interpolation of "High Power Rap" by Crash Crew. The song has additional vocals sung by Q-Tip, Slick Rick and Biz Markie, but are not credited as featured guests on the back artwork, they are however credited in the album's liner notes. Actresses Carmen Electra, Paula Jai Parker, Taraji P. Henson, and Tamala Jones all make cameo appearances in the song's music video.
A remix to the song produced by Kanye West can be found as a hidden track on The Blueprint album after the songs "Blueprint (Momma Loves Me)" and the other hidden song "Lyrical Exercise". The remix is composed of new verses by Jay-Z, a new instrumental sampling "Trying Girls Out" by The Persuaders and uncredited vocals from Michael Jackson.